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Target
Gag-Pol polyprotein [588-1147,M628L,N654N,K657R,T802F,K807E]
Ligand
BDBM77145
Substrate
n/a
Meas. Tech.
PHENOSENSE assay
IC50
6515±0.0 nM
Citation
 Lanier, ER Methods of treating retroviral infections and related dosage regimes US Patent  US9694024 Publication Date 7/4/2017 
Target
Name:
Gag-Pol polyprotein [588-1147,M628L,N654N,K657R,T802F,K807E]
Synonyms:
HIV RT (41L/67N/70R/215F/219E) | POL_HV1H2 | gag-pol
Type:
n/a
Mol. Mass.:
64541.40
Organism:
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)
Description:
P04585[588-1147,M628L,N654N,K657R,T802F,K807E]
Residue:
560
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLFTPDEKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVL
  
Inhibitor
Name:
BDBM77145
Synonyms:
9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine | PMPA prodrug | Tenofovir | Tenofovir disoproxil
Type:
Small organic molecule
Emp. Form.:
C19H30N5O10P
Mol. Mass.:
519.4428
SMILES:
CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)OCOC(=O)OC(C)C
Structure:
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