Reaction Details Report a problem with these data
Target
Retinoic acid receptor alpha [200-419]
Ligand
BDBM31886
Substrate
BDBM31883
Meas. Tech.
Retinoid Competition Binding Assay
pH
7.9000±n/a
Temperature
277.1500±n/a K
Kd
118±n/a nM
Citation
 Klaholz, BP; Mitschler, A; Moras, D Structural basis for isotype selectivity of the human retinoic acid nuclear receptor. J Mol Biol 302:155-70 (2000) [PubMed]  Article 
Target
Name:
Retinoic acid receptor alpha [200-419]
Synonyms:
RARA_HUMAN | RARA | NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | Retinoic Acid Receptor, alpha
Type:
Ligand-binding domain
Mol. Mass.:
24746.59
Organism:
Human
Description:
P10276[200-419]
Residue:
220
Sequence:
PALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG
  
Inhibitor
Name:
BDBM31886
Synonyms:
CHEMBL309282 | CD564
Type:
Small organic molecule
Emp. Form.:
C26H26O3
Mol. Mass.:
386.19
SMILES:
CC1(CCC(c2c1ccc(c2)C(=O)c3ccc4cc(ccc4c3)C(=O)O)(C)C)C
Structure:
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Substrate
Name:
BDBM31883
Synonyms:
ALL-TRANS-RETINOIC ACID | SMR000058245 | cid_444795 | [3H]RA | AT-RA | TRETINOIN | [3H]tretinoin | all-trans retinoic acid | CHEMBL38 | Vitamin A acid | MLS000028588 | [3H]Vitamin A acid | 9-cis-retinoic acid (9cRA) | [3H]Retinoic acid | Atralin
Type:
radiolabeled ligand
Emp. Form.:
C20H28O2
Mol. Mass.:
300.21
SMILES:
CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C
Structure:
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