Reaction Details Report a problem with these data
Target
Retinoic acid receptor alpha [200-419]
Ligand
BDBM31889
Substrate
BDBM31883
Meas. Tech.
Retinoid Competition Binding Assay
pH
7.9±n/a
Temperature
277.15±n/a K
Comments
No binding.
Citation
Klaholz, BP; Mitschler, A; Moras, D Structural basis for isotype selectivity of the human retinoic acid nuclear receptor. J Mol Biol 302:155-70 (2000) [PubMed] Article
More Info.:
Target
Name:
Retinoic acid receptor alpha [200-419]
Synonyms:
NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | RARA_HUMAN | Retinoic Acid Receptor, alpha
Type:
Ligand-binding domain
Mol. Mass.:
24746.59
Organism:
Human
Description:
P10276[200-419]
Residue:
220
Sequence:
PALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG
Inhibitor
Name:
BDBM31889
Synonyms:
BMS 961 | BMS270394 | BMS961
Type:
Small organic molecule
Emp. Form.:
C23H26FNO4
Mol. Mass.:
399.4552
SMILES:
CC1(C)CCC(C)(C)c2cc(ccc12)[C@@H](O)C(=O)Nc1ccc(cc1F)C(O)=O
Substrate
Name:
BDBM31883
Synonyms:
9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC ACID | AT-RA | Atralin | CHEMBL38 | MLS000028588 | SMR000058245 | TRETINOIN | Vitamin A acid | [3H]RA | [3H]Retinoic acid | [3H]Vitamin A acid | [3H]tretinoin | all-trans retinoic acid | cid_444795
Type:
radiolabeled ligand
Emp. Form.:
C20H28O2
Mol. Mass.:
300.4351
SMILES:
C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4|