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Target
Putative hydrolase
Ligand
BDBM50115668
Substrate
n/a
Meas. Tech.
Biochemical Characterization of Cif Inhibitors
IC50
>100000±n/a nM
Citation
 Madden, DR; Bahl, CD; Hammock, BD; Morisseau, C Compounds and methods for inhibiting Cif virulence factor US Patent  US10322118 Publication Date 6/18/2019 
Target
Name:
Putative hydrolase
Synonyms:
CFTR inhibitory factor, Cif | Putative hydrolase | cif
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35786.52
Organism:
Pseudomonas aeruginosa (strain UCBPP-PA14)
Description:
A0A0H2ZD27
Residue:
319
Sequence:
MILDRLCRGLLAGIALTFSLGGFAAEEFPVPNGFESAYREVDGVKLHYVKGGQGPLVMLVHGFGQTWYEWHQLMPELAKRFTVIAPDLPGLGQSEPPKTGYSGEQVAVYLHKLARQFSPDRPFDLVAHDIGIWNTYPMVVKNQADIARLVYMEAPIPDARIYRFPAFTAQGESLVWHFSFFAADDRLAETLIAGKERFFLEHFIKSHASNTEVFSERLLDLYARSYAKPHSLNASFEYYRALNESVRQNAELAKTRLQMPTMTLAGGGHGGMGTFQLEQMKAYAEDVEGHVLPGCGHWLPEECAAPMNRLVIDFLSRGR
  
Inhibitor
Name:
BDBM50115668
Synonyms:
3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxyacetic acid | CHEMBL107400 | GC-1 | US10322118, Entry 7 | US10544075, Compound GC-1 | [4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phenoxy]-acetic acid | [4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phenoxy]-acetic acid(GC-1) | {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid
Type:
Small organic molecule
Emp. Form.:
C20H24O4
Mol. Mass.:
328.4022
SMILES:
CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)ccc1O
Structure:
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