Reaction Details Report a problem with these data
Target
Dimer of Gag-Pol polyprotein [501-599,D531N,M537I]
Ligand
BDBM520
Substrate
Chromogenic peptide substrate
Meas. Tech.
Protease Inhibition Assay
pH
4.7±n/a
Temperature
310.15±n/a K
Ki
4.5±0.3 nM
Km
22000±2000 nM
kcat
4.9±0.3 1/sec
Citation
 Clemente, JC; Hemrajani, R; Blum, LE; Goodenow, MM; Dunn, BM Secondary mutations M36I and A71V in the human immunodeficiency virus type 1 protease can provide an advantage for the emergence of the primary mutation D30N. Biochemistry 42:15029-35 (2003) [PubMed]  Article 
Target
Name:
Dimer of Gag-Pol polyprotein [501-599,D531N,M537I]
Synonyms:
HIV-1 Protease Mutant (D30N/M36I)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [501-599,D531N,M537I]
Synonyms:
HIV-1 Protease Mutant (D30N/M36I) chain A | HIV-1 Protease Mutant (D30N/M36I) chain B | LAI (D30N/M36I) | POL_HV1BR | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10777.17
Organism:
Human immunodeficiency virus type 1
Description:
P03367[501-599,D531N,M537I]
Residue:
99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEISLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Component 2
Name:
Gag-Pol polyprotein [501-599,D531N,M537I]
Synonyms:
HIV-1 Protease Mutant (D30N/M36I) chain A | HIV-1 Protease Mutant (D30N/M36I) chain B | LAI (D30N/M36I) | POL_HV1BR | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10777.17
Organism:
Human immunodeficiency virus type 1
Description:
P03367[501-599,D531N,M537I]
Residue:
99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEEISLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM520
Synonyms:
1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[(2S)-3-methyl-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}butanamido]-1,6-diphenylhexan-2-yl]carbamate | ABT-538 | CHEMBL163 | Norvir | RTV | Ritonavir
Type:
Small organic molecule
Emp. Form.:
C37H48N6O5S2
Mol. Mass.:
720.944
SMILES:
CC(C)[C@H](NC(=O)N(C)Cc1csc(n1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Chromogenic peptide substrate
Synonyms:
Chromogenic peptide substrate
Type:
Peptide
Mol. Mass.:
1420.11
Organism:
n/a
Description:
n/a
Residue:
13
Sequence:
KARVLNPHEANLG