Target
Oxysterols receptor LXR-alpha [197-447]
Ligand
BDBM35094
Substrate
BDBM19993
Meas. Tech.
LXRbeta Binding Assay (IC50) and LAFbeta Functional Assay (EC50)
IC50
10.2±n/a nM
Citation
 Bernotas, RCKaufman, DHSinghaus, RRUllrich, JUnwalla, RQuinet, ENambi, PWilhelmsson, AGoos-Nilsson, AWrobel, J 4-(3-aryloxyaryl)quinoline alcohols are liver X receptor agonists. Bioorg Med Chem 17:8086-92 (2009) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-alpha [197-447]
Synonyms:
LXRA | Liver X Receptor alpha (LXR-alpha) | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 | Oxysterols receptor LXR-alpha
Type:
Receptor
Mol. Mass.:
28986.41
Organism:
Homo sapiens (Human)
Description:
LXR alpha ligand binding domain (amino acid residues 197-447) with an N-terminal biotinylation tag expressed in E.coli, was used for the binding assays.
Residue:
251
Sequence:
SSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM35094
Synonyms:
biarylether alcohol quinoline, 5f
Type:
Small organic molecule
Emp. Form.:
C24H18F3NO2
Mol. Mass.:
409.4004
SMILES:
Cc1cnc2c(cccc2c1-c1cccc(Oc2cccc(CO)c2)c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM19993
Synonyms:
CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide | T 0901317 | T0901317 | TO-901317 | US10543183, Compound TO901317 | US10669296, Compound TO901317 | US10945978, Compound 1 | [3H]T0901317
Type:
Small organic molecule
Emp. Form.:
C17H12F9NO3S
Mol. Mass.:
481.333
SMILES:
OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: