Reaction Details Report a problem with these data
Target
m7GpppX diphosphatase
Ligand
BDBM50232538
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
7.62±0.0 nM
EC50
4.0±0.0 nM
Citation
 Singh, J; Salcius, M; Liu, SW; Staker, BL; Mishra, R; Thurmond, J; Michaud, G; Mattoon, DR; Printen, J; Christensen, J; Bjornsson, JM; Pollok, BA; Kiledjian, M; Stewart, L; Jarecki, J; Gurney, ME DcpS as a therapeutic target for spinal muscular atrophy. ACS Chem Biol 3:711-22 (2008) [PubMed]  Article 
Target
Name:
m7GpppX diphosphatase
Synonyms:
DCPS_HUMAN | DCPS | DCS1 | HINT5 | Scavenger mRNA-decapping enzyme (DcpS)
Type:
Enzyme
Mol. Mass.:
38606.80
Organism:
Human
Description:
Q96C86
Residue:
337
Sequence:
MADAAPQLGKRKRELDVEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQS
  
Inhibitor
Name:
BDBM50232538
Synonyms:
D156844 | CHEMBL251429 | 5-((1-(2-fluorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine | 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
c1ccc(c(c1)CN2CCC(CC2)COc3cccc4c3c(nc(n4)N)N)F
Structure:
Search PDB for entries with ligand similarity: