Target
Fibroblast growth factor receptor 4
Ligand
BDBM91653
Substrate
n/a
Meas. Tech.
Omnia Assay
pH
7.5±n/a
IC50
<100±n/a nM
Comments
extracted
Citation
 D'Agostino, LASjin, RTNiu, DMcDonald, JJZhu, ZLiu, HMazdiyasni, HPetter, RCSingh, JBarrague, MGross, AMunson, M Heteroaryl compounds and uses thereof US Patent  US9695132 Publication Date 7/4/2017 
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF
Type:
Protein
Mol. Mass.:
87957.45
Organism:
Homo sapiens (Human)
Description:
P22455
Residue:
802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM91653
Synonyms:
US10189794, Compound I-59 | US10618902, Compound I-59 | US10774052, Compound I-59 | US9695132, I-59
Type:
Small organic molecule
Emp. Form.:
C26H28N6O5
Mol. Mass.:
504.5377
SMILES:
COCCN1C(=O)N(Cc2cnc(Nc3ccccc3NC(=O)C=C)nc12)c1cc(OC)cc(OC)c1 |$;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;;;;$|
Structure:
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