Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid type B receptor subunit 1
Ligand
BDBM403328
Substrate
n/a
Meas. Tech.
Steroid Inhibition of TBPS Binding
IC50
<10±n/a nM
Citation
 Robichaud, AJ; Salituro, FG; Harrison, BL; Martinez Botella, G Neuroactive steroids, compositions, and uses thereof US Patent  US10329320 Publication Date 6/25/2019 
Target
Name:
Gamma-aminobutyric acid type B receptor subunit 1
Synonyms:
GABA B | Gamma-aminobutyric acid type B receptor subunit 1 (GABA) | GABR1_RAT | Gabbr1 | Gamma-aminobutyric acid (GABA) B receptor 1 | Gb1 | GABA-B-R1 | GABA-B receptor 1 | GABA uptake | GABA-BR1 | GABA B receptor | GABABR1
Type:
Protein
Mol. Mass.:
108221.06
Organism:
Rat
Description:
Q9Z0U4
Residue:
960
Sequence:
MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
  
Inhibitor
Name:
BDBM403328
Synonyms:
US10329320, Compound 1 | US10329320, Compound 2
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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