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Target
Heat shock factor protein 1
Ligand
BDBM48210
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
<160±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM48210
Synonyms:
2-[4-[(5-tert-butyl-2-furoyl)amino]phenyl]acetic acid | 2-[4-[(5-tert-butylfuran-2-carbonyl)amino]phenyl]acetic acid | 2-[4-[(5-tert-butylfuran-2-yl)carbonylamino]phenyl]ethanoic acid | 2-[4-[[(5-tert-butyl-2-furanyl)-oxomethyl]amino]phenyl]acetic acid | MLS000123017 | SMR000123680 | cid_778068 | {4-[(5-tert-Butyl-furan-2-carbonyl)-amino]-phenyl}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C17H19NO4
Mol. Mass.:
301.3371
SMILES:
CC(C)(C)c1ccc(o1)C(=O)Nc1ccc(CC(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: