Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM63880
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
<160±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM63880
Synonyms:
1-(tert-butyl)-4-[({[(3,4-dichloroanilino)carbonyl]oxy}imino)methyl]-3,5-dimethyl-1H-pyrazole | MLS000851306 | N-(3,4-dichlorophenyl)carbamic acid [(1-tert-butyl-3,5-dimethyl-4-pyrazolyl)methylideneamino] ester | N-(3,4-dichlorophenyl)carbamic acid [(1-tert-butyl-3,5-dimethyl-pyrazol-4-yl)methyleneamino] ester | SMR000457649 | [(1-tert-butyl-3,5-dimethyl-pyrazol-4-yl)methylideneamino] N-(3,4-dichlorophenyl)carbamate | [(1-tert-butyl-3,5-dimethylpyrazol-4-yl)methylideneamino] N-(3,4-dichlorophenyl)carbamate | cid_2804819
Type:
Small organic molecule
Emp. Form.:
C17H20Cl2N4O2
Mol. Mass.:
383.272
SMILES:
Cc1nn(c(C)c1C=NOC(=O)Nc1ccc(Cl)c(Cl)c1)C(C)(C)C |w:8.9|
Structure:
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