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Target
Heat shock factor protein 1
Ligand
BDBM64152
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
<160±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM64152
Synonyms:
2-(2,3-dihydro-1,4-benzodioxin-3-yl)-5-propylsulfonyl-4-pyrimidinamine | 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-5-propylsulfonyl-pyrimidin-4-amine | 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-5-propylsulfonylpyrimidin-4-amine | MLS001182084 | SMR000567771 | [2-(2,3-dihydro-1,4-benzodioxin-3-yl)-5-propylsulfonyl-pyrimidin-4-yl]amine | cid_2823045
Type:
Small organic molecule
Emp. Form.:
C15H17N3O4S
Mol. Mass.:
335.378
SMILES:
CCCS(=O)(=O)c1cnc(nc1N)C1COc2ccccc2O1
Structure:
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