Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM62439
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
170±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM62439
Synonyms:
MLS000570595 | N'-[3-(1,3-benzodioxol-5-yl)-2-propen-1-ylidene]-2-(2,3-dimethylphenoxy)acetohydrazide | N-[[(E)-3-(1,3-benzodioxol-5-yl)prop-2-enylidene]amino]-2-(2,3-dimethylphenoxy)acetamide | N-[[(E)-3-(1,3-benzodioxol-5-yl)prop-2-enylidene]amino]-2-(2,3-dimethylphenoxy)ethanamide | SMR000187020 | cid_2263315
Type:
Small organic molecule
Emp. Form.:
C20H20N2O4
Mol. Mass.:
352.3838
SMILES:
Cc1cccc(OCC(=O)NN=C\C=C\c2ccc3OCOc3c2)c1C
Structure:
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