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Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM66400
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
<160±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM66400
Synonyms:
(E)-3-phenyl-N-[2,2,2-trichloro-1-[(4-methoxyphenyl)carbamothioylamino]ethyl]prop-2-enamide | (E)-3-phenyl-N-[2,2,2-trichloro-1-[(4-methoxyphenyl)thiocarbamoylamino]ethyl]acrylamide | (E)-3-phenyl-N-[2,2,2-trichloro-1-[[(4-methoxyanilino)-sulfanylidenemethyl]amino]ethyl]-2-propenamide | (E)-3-phenyl-N-[2,2,2-tris(chloranyl)-1-[(4-methoxyphenyl)carbamothioylamino]ethyl]prop-2-enamide | 3-phenyl-N-[2,2,2-trichloro-1-({[(4-methoxyphenyl)amino]carbonothioyl}amino)ethyl]acrylamide | MLS000573668 | SMR000184517 | cid_5717736
Type:
Small organic molecule
Emp. Form.:
C19H18Cl3N3O2S
Mol. Mass.:
458.789
SMILES:
COc1ccc(NC(=S)NC(NC(=O)C=Cc2ccccc2)C(Cl)(Cl)Cl)cc1 |w:14.13|
Structure:
Search PDB for entries with ligand similarity: