Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM68172
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
<160±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM68172
Synonyms:
4-(dichloromethyl)-2-(4-nitrophenyl)quinazoline | 4-Dichloromethyl-2-(4-nitro-phenyl)-quinazoline | 4-[bis(chloranyl)methyl]-2-(4-nitrophenyl)quinazoline | MLS001044463 | SMR000424835 | cid_911287
Type:
Small organic molecule
Emp. Form.:
C15H9Cl2N3O2
Mol. Mass.:
334.157
SMILES:
[O-][N+](=O)c1ccc(cc1)-c1nc(C(Cl)Cl)c2ccccc2n1
Structure:
Search PDB for entries with ligand similarity: