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Target
Beta-hexosaminidase subunit alpha
Ligand
BDBM50106194
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
Temperature
298.1500±0.0000 K
IC50
1.8e+4± 1.5e+3 nM
Citation
 Tropak, MB; Blanchard, JE; Withers, SG; Brown, ED; Mahuran, D High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones. Chem Biol 14:153-64 (2007) [PubMed]  Article 
Target
Name:
Beta-hexosaminidase subunit alpha
Synonyms:
Beta-N-acetylhexosaminidase subunit alpha | HEXA_HUMAN | HEXA | Beta-hexosaminidase subunit alpha (HexA)
Type:
Protein
Mol. Mass.:
60688.46
Organism:
Human
Description:
P06865
Residue:
529
Sequence:
MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT
  
Inhibitor
Name:
BDBM50106194
Synonyms:
BTB12933 | CHEMBL339586 | 1,3-dioxo-1H-benz[de]isoquinoline | 1,8-Naphthalimide | Benzo[de]isoquinoline-1,3-dione | 1H-benzo[de]isoquinoline-1,3(2H)-dione
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
c1cc2cccc3c2c(c1)C(=O)NC3=O
Structure:
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