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Target
NACHT, LRR and PYD domains-containing protein 3
Ligand
BDBM76295
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for the identification of inhibitors of NALP3 in yeast using a luminescent assay
IC50
4070±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for the identification of inhibitors of NALP3 in yeast using a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
NACHT, LRR and PYD domains-containing protein 3
Synonyms:
C1orf7 | CIAS1 | NALP3 | NLRP3 | NLRP3 protein | NLRP3_HUMAN | PYPAF1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
118173.88
Organism:
Homo sapiens (Human)
Description:
Q96P20
Residue:
1036
Sequence:
MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW
  
Inhibitor
Name:
BDBM76295
Synonyms:
MLS001234095 | N-[2-(1-cyclohexenyl)ethyl]-5-hydroxy-3-methyl-7-oxo-6-thiazolo[3,2-a]pyrimidinecarboxamide | N-[2-(cyclohexen-1-yl)ethyl]-3-methyl-5-oxidanyl-7-oxidanylidene-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide | N-[2-(cyclohexen-1-yl)ethyl]-5-hydroxy-3-methyl-7-oxo-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide | N-[2-(cyclohexen-1-yl)ethyl]-5-hydroxy-7-keto-3-methyl-thiazolo[3,2-a]pyrimidine-6-carboxamide | SMR000811836 | cid_18575872
Type:
Small organic molecule
Emp. Form.:
C16H19N3O3S
Mol. Mass.:
333.405
SMILES:
Cc1csc2nc(=O)c(C(=O)NCCC3=CCCCC3)c(O)n12 |t:14|
Structure:
Search PDB for entries with ligand similarity: