Reaction Details Report a problem with these data
Target
Putative farnesyl pyrophosphate synthase
Ligand
BDBM12578
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.7000±0.0000
Temperature
310.1500±0.0000 K
Ki
0.050±0.038 nM
IC50
30.1±1.1 nM
Citation
 Artz, JD; Dunford, JE; Arrowood, MJ; Dong, A; Chruszcz, M; Kavanagh, KL; Minor, W; Russell, RG; Ebetino, FH; Oppermann, U; Hui, R Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis. Chem Biol 15:1296-306 (2008) [PubMed]  Article 
Target
Name:
Putative farnesyl pyrophosphate synthase
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
44960.82
Organism:
Cryptosporidium parvum (strain Iowa II)
Description:
Belongs to the FPP/GGPP synthase family. Q5CR09
Residue:
384
Sequence:
ILFHLLKITFIDSIFFALHDNYLTPQFIFNKMNDLQIEYDYTDFINYYDKFKVIVYNVLKKLPLNDEIRKPVIEYYLNCIDYNVKKGKHIRGKILVLISSLSSAYSNIKRDSIYLLGWVVEAIQALILIADDIMDSGKFRRGAPCWYIVHGQSNAINDIFFLKMLSLSLIFELSSVFGNDIVMKIQKIYNESIFFTVLGQHLDLSYFDLSKADKISERYFSMVEMKTSRYTFYMPVFFGLTLSEIQVSSAQLNLIEAILYKLGEFYQVHNDVSDYLFNDSNADDICRFKLTWPLQKSFEIADEEMKLKISENYGKNSSLVKDCYNLLKINEHYLEYQRNALDYLIKLVKDITDDSLQKVFIHLIHQISELITNSRSNADSNNSL
  
Inhibitor
Name:
BDBM12578
Synonyms:
CHEMBL924 | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid | JMC515594 Compound 55 | ZOL | Bisphosphonate 3 | 2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid | zoledronic acid | Zometa | CGP-42446 | Reclast | Zoledronate | US11279719, Example Zolendronic acid (ZOL)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: