Reaction Details
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5-hydroxytryptamine receptor 2C
Ligand
BDBM50056401
Substrate
n/a
Ki
3981.07±n/a nM
Comments
PDSP_1689
Citation
Buchheit, KH; Gamse, R; Pfannkuche, HJ SDZ 205-557, a selective, surmountable antagonist for 5-HT4 receptors in the isolated guinea pig ileum. Naunyn Schmiedebergs Arch Pharmacol 345:387-93 (1992) [PubMed] Article More Info.:
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT2C | HTR2C
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51519.58
Organism:
PIG
Description:
G7ZKZ7
Residue:
457
Sequence:
MVNLRKAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIILTIGGNILVIMAVSLEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAVRGPVEHSRFNSRTKAIMKIAIVWAISLGVSVPIPVIGLRDEDKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIHVLRRQALMLLRGHTEEPPGISLDFLKCCKRNTDEESAANPNQDLNPRRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKVYRRAFSNYLRCNYKADKKPPIRQIPRVAATALSGRELNVNIYRHTNEPVIKKADDNEPGIEMQVENLELPVNPSNVVSERISSV
Inhibitor
Name:
BDBM50056401
Synonyms:
2-diethylaminoethyl [2-methoxy-4-amino-5-chloro]benzoate | 4-Amino-5-chloro-2-methoxy-benzoic acid 2-diethylamino-ethyl ester | CHEMBL287045 | SDZ 205557 | SDZ-205557
Type:
Small organic molecule
Emp. Form.:
C14H21ClN2O3
Mol. Mass.:
300.781
SMILES:
CCN(CC)CCOC(=O)c1cc(Cl)c(N)cc1OC
Structure:
