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Target
Heat shock 70 kDa protein 1A
Ligand
BDBM82124
Substrate
n/a
Meas. Tech.
Fluorescence-Polarization (FP) Binding Assay
pH
7.4±0
Temperature
298.15±0 K
Ki
1.1e+2±n/a nM
Citation
 Macias, AT; Williamson, DS; Allen, N; Borgognoni, J; Clay, A; Daniels, Z; Dokurno, P; Drysdale, MJ; Francis, GL; Graham, CJ; Howes, R; Matassova, N; Murray, JB; Parsons, R; Shaw, T; Surgenor, AE; Terry, L; Wang, Y; Wood, M; Massey, AJ Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity. J Med Chem 54:4034-41 (2011) [PubMed]  Article 
Target
Name:
Heat shock 70 kDa protein 1A
Synonyms:
HS71A_HUMAN | HSP70-1/HSP70-2 | HSP70.1 | HSP72 | HSPA1 | HSPA1A | HSX70 | Heat Shock 70kDa Protein 1 | Heat shock 70 kDa protein 1A/1B | Hsp70
Type:
Chaperone
Mol. Mass.:
70043.82
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
641
Sequence:
MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
  
Inhibitor
Name:
BDBM82124
Synonyms:
adenosine-derived inhibitor (Grp78), 1
Type:
Small organic molecule
Emp. Form.:
C10H14N5O10P2
Mol. Mass.:
426.1937
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]1O |r|
Structure:
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