Reaction Details Report a problem with these data
Target
Ephrin type-A receptor 4 [1-949,A922V]
Ligand
BDBM82188
Substrate
n/a
Meas. Tech.
Enzyme-linked Immunosorbent Assay
pH
7.5000±0.0000
IC50
>5.00e+5±n/a nM
Citation
 Noberini, R; De, SK; Zhang, Z; Wu, B; Raveendra-Panickar, D; Chen, V; Vazquez, J; Qin, H; Song, J; Cosford, ND; Pellecchia, M; Pasquale, EB A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors. Chem Biol Drug Des 78:667-78 (2011) [PubMed]  Article 
Target
Name:
Ephrin type-A receptor 4 [1-949,A922V]
Synonyms:
EPHA4_HUMAN | EPHA4 | HEK8 | SEK | TYRO1
Type:
Protein
Mol. Mass.:
105739.43
Organism:
Human
Description:
Q58F15
Residue:
949
Sequence:
MAGIFYFALFSCLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNCLCNAGHEERSGECQACKIGYYKALSTDATCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTKVSITDLLAHTNYTFEIWAVNGVSKYNPNPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESSRPNTALLDPSSPEFSAVVSVGDWLQVIKMDRYKDNFTAAGYTTLEAVVHVNQE
  
Inhibitor
Name:
BDBM82188
Synonyms:
Salicylic acid derivative, 76A5
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
OC(=O)\C=C\c1ccc(o1)-c1ccc(O)c(c1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: