Reaction Details
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Inner capsid protein sigma-2
Ligand
BDBM82273
Substrate
n/a
Ki
15.84±n/a nM
Comments
PDSP_1621
Citation
Hegde, SS; Bonhaus, DW; Johnson, LG; Leung, E; Clark, RD; Eglen, RM RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist. Br J Pharmacol 115:1087-95 (1995) [PubMed] Article More Info.:
Target
Name:
Inner capsid protein sigma-2
Synonyms:
Sigma-2 | SIGM2_REOVL | S2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47118.43
Organism:
T1L
Description:
P11314
Residue:
418
Sequence:
MARAAFLFKTVGFGGLQNVPINDELSSHLLRAGNSPWQLTQFLDWISLGRGLATSALVPTAGSRYYQMSCLLSGTLQIPFRPNHRWGDIRFLRLVWSAPTLDGLVVAPPQVLAQPALQAQADRVYDCDDYPFLARDPRFKHRVYQQLSAVTLLNLTGFGPISYVRVDEDMWSGDVNQLLMNYFGHTFAEIAYTLCQASANRPWEHDGTYARMTQIILSLFWLSYVGVIHQQNTYRTFYFQCNRRGDAAEVWILSCSLNHSAQIRPGNRSLFVMPTSPDWNMDVNLILSSTLTGCLCSGSQLPLIDNNSVPAVSRNIHGWTGRAGNQLHGFQVRRMVTEFCDRLRRDGVMTQAQQNQIEALADQTQQFKRDKLEAWAREDDQYNQANPNSTMFRTKPFTNAQWGRGNTGATSAAIAALI
Inhibitor
Name:
BDBM82273
Synonyms:
CAS_167710-87-4 | RS 39604
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1
Structure:
