Reaction Details
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5-hydroxytryptamine receptor 5A
Ligand
BDBM50010301
Substrate
n/a
Ki
1000±n/a nM
Comments
PDSP_1725
Citation
Erlander, MG; Lovenberg, TW; Baron, BM; de Lecea, L; Danielson, PE; Racke, M; Slone, AL; Siegel, BW; Foye, PE; Cannon, K Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain. Proc Natl Acad Sci U S A 90:3452-6 (1993) [PubMed] Article More Info.:
Target
Name:
5-hydroxytryptamine receptor 5A
Synonyms:
REC17 | 5-hydroxytryptamine receptor 5A | Serotonin receptor 5A | 5-HT5a | 5-HT-5A | 5HT5A_RAT | Htr5a | 5ht5a | Serotonin (5-HT) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40684.21
Organism:
Rat
Description:
5-HT5a HTR5A RAT::P35364
Residue:
357
Sequence:
MDLPINLTSFSLSTPSTLEPNRSLDTEALRTSQSFLSAFRVLVLTLLGFLAAATFTWNLLVLATILRVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRARKRVSNVMILLTWALSAVISLAPLLFGWGETYSELSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYKAAKFRMGSRKTNSVSPIPEAVEVKDASQHPQMVFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDIPALWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ
Inhibitor
Name:
BDBM50010301
Synonyms:
SKF 83566 | CHEMBL324017 | 8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol(SKF 83566)
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CN1CCc2cc(Br)c(O)cc2C(C1)c1ccccc1
Structure:
