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Target
Baculoviral IAP repeat-containing protein 2
Ligand
BDBM50240586
Substrate
n/a
Meas. Tech.
ChEMBL_1668462 (CHEMBL4018350)
IC50
1.1±n/a nM
Citation
 Manzoni, L; Samela, A; Barbini, S; Cairati, S; Penconi, M; Arosio, D; Lecis, D; Seneci, P 4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn Bioorg Med Chem Lett 27:2336-2344 (2017) [PubMed]  Article 
Target
Name:
Baculoviral IAP repeat-containing protein 2
Synonyms:
Cellular inhibitor of apoptosis 1 | Baculoviral IAP repeat-containing protein 2 (cIAP1) | Inhibitor of apoptosis protein 2 (cIAP1) | BIRC2_HUMAN | BIRC2 | API1 | MIHB | RNF48
Type:
Protein
Mol. Mass.:
69900.47
Organism:
Human
Description:
Q13490
Residue:
618
Sequence:
MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS
  
Inhibitor
Name:
BDBM50240586
Synonyms:
CHEMBL4098982
Type:
Small organic molecule
Emp. Form.:
C45H55N9O5
Mol. Mass.:
801.43
SMILES:
[H][C@]12CC[C@H](N1C(=O)[C@@H](NC(=O)[C@H](CC)NC)[C@@H](CNC(=O)c1ccccc1)CC2)C(=O)N[C@H](C(=O)NCCN(Cc1ccccn1)Cc1ccccn1)c1ccccc1 |r|
Structure:
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