Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50243976
Substrate
n/a
Meas. Tech.
ChEMBL_1673159 (CHEMBL4023188)
EC50
>50000±n/a nM
Citation
 Shi, JGu, ZJurica, EAWu, XHaque, LEWilliams, KNHernandez, ASHong, ZGao, QDabros, MDavulcu, AHMathur, ARampulla, RAGupta, AKJayaram, RApedo, AMoore, DBLiu, HKunselman, LKBrady, EJWilkes, JJZinker, BACai, HShu, YZSun, QDierks, EAFoster, KAXu, CWang, TPanemangalore, RCvijic, MEXie, CCao, GGZhou, MKrupinski, JWhaley, JMRobl, JAEwing, WREllsworth, BA Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists. J Med Chem 61:681-694 (2018) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50243976
Synonyms:
CHEMBL4105324
Type:
Small organic molecule
Emp. Form.:
C25H27F4N3O4
Mol. Mass.:
509.4932
SMILES:
COc1ccc(F)c(c1)N1CCC(CC1)Oc1ccc(cc1)N1N=C([C@@H](C)[C@@H]1CC(O)=O)C(F)(F)F |r,c:26|
Structure:
Search PDB for entries with ligand similarity: