Target
Neutrophil elastase
Ligand
BDBM50004191
Substrate
n/a
Meas. Tech.
ChEBML_63655
pH
7.5±n/a
IC50
11100±n/a nM
Comments
extracted
Citation
 Skiles, JWMiao, CSorcek, RJacober, SMui, PWChow, GWeldon, SMPossanza, GSkoog, MKeirns, J Inhibition of human leukocyte elastase by N-substituted peptides containing alpha,alpha-difluorostatone residues at P1. J Med Chem 35:4795-808 (1993) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50004191
Synonyms:
4-{2-[(2-Benzyloxycarbonylamino-3-methyl-butyryl)-indan-2-yl-amino]-acetylamino}-2,2-difluoro-6-methyl-3-oxo-heptanoic acid ethyl ester | CHEMBL445912
Type:
Small organic molecule
Emp. Form.:
C34H43F2N3O7
Mol. Mass.:
643.7179
SMILES:
CCOC(=O)C(F)(F)C(=O)C(CC(C)C)NC(=O)CN(C1Cc2ccccc2C1)C(=O)C(NC(=O)OCc1ccccc1)C(C)C
Structure:
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