Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50003363
Substrate
n/a
Meas. Tech.
ChEMBL_138793 (CHEMBL752318)
IC50
4.8±n/a nM
Citation
 Sauerberg, POlesen, PHNielsen, STreppendahl, SSheardown, MJHonoré, TMitch, CHWard, JSPike, AJBymaster, FP Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines . J Med Chem 35:2274-83 (1992) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
Rat
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50003363
Synonyms:
1-Methyl-5-(4-pentylsulfanyl-[1,2,5]thiadiazol-3-yl)-1,2,3,6-tetrahydro-pyridine | 1-Methyl-5-(4-pentylsulfanyl-[1,2,5]thiadiazol-3-yl)-1,2,3,6-tetrahydro-pyridine; oxalic acid | CHEMBL130715 | CHEMBL308381
Type:
Small organic molecule
Emp. Form.:
C13H21N3S2
Mol. Mass.:
283.456
SMILES:
CCCCCSc1nsnc1C1=CCCN(C)C1 |t:12|
Structure:
Search PDB for entries with ligand similarity: