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Target
Polycomb protein EED
Ligand
BDBM50259901
Substrate
n/a
Meas. Tech.
ChEBML_1691994
IC50
>500000±n/a nM
Citation
 Lingel, A; Sendzik, M; Huang, Y; Shultz, MD; Cantwell, J; Dillon, MP; Fu, X; Fuller, J; Gabriel, T; Gu, J; Jiang, X; Li, L; Liang, F; McKenna, M; Qi, W; Rao, W; Sheng, X; Shu, W; Sutton, J; Taft, B; Wang, L; Zeng, J; Zhang, H; Zhang, M; Zhao, K; Lindvall, M; Bussiere, DE Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase. J Med Chem 60:415-427 (2017) [PubMed]  Article 
Target
Name:
Polycomb protein EED
Synonyms:
EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED
Type:
Protein
Mol. Mass.:
50201.68
Organism:
Homo sapiens (Human)
Description:
O75530
Residue:
441
Sequence:
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
  
Inhibitor
Name:
BDBM50259901
Synonyms:
CHEMBL1618229
Type:
Small organic molecule
Emp. Form.:
C12H17N
Mol. Mass.:
175.2701
SMILES:
C(C1CCCNC1)c1ccccc1
Structure:
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