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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50262403
Substrate
n/a
Meas. Tech.
ChEBML_1696795
IC50
400±n/a nM
Citation
 Barberis, C; Moorcroft, N; Arendt, C; Levit, M; Moreno-Mazza, S; Batchelor, J; Mechin, I; Majid, T Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I. Bioorg Med Chem Lett 27:4730-4734 (2017) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Human
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50262403
Synonyms:
CHEMBL4080621
Type:
Small organic molecule
Emp. Form.:
C25H25ClN4O
Mol. Mass.:
432.945
SMILES:
Cn1c(c(-c2ccc(CO)cc2)c2c(Cl)ccnc12)-c1ccc(cc1)N1CCNCC1
Structure:
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