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Target
Bile acid receptor
Ligand
BDBM50268318
Substrate
n/a
Meas. Tech.
ChEMBL_1704812 (CHEMBL4056045)
Kd
48700±n/a nM
Citation
 Wang, H; Zhao, Z; Zhou, J; Guo, Y; Wang, G; Hao, H; Xu, X A novel intestinal-restricted FXR agonist. Bioorg Med Chem Lett 27:3386-3390 (2017) [PubMed]  Article 
Target
Name:
Bile acid receptor
Synonyms:
Farnesol receptor HRR-1 | Nuclear receptor subfamily 1 group H member 4 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor | NR1H4_HUMAN | NR1H4 | BAR | FXR | HRR1 | RIP14 | Bile acid receptor FXR
Type:
Nuclear Receptor
Mol. Mass.:
55916.24
Organism:
Human
Description:
Q96RI1
Residue:
486
Sequence:
MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
  
Inhibitor
Name:
BDBM50268318
Synonyms:
CHEMBL4097177
Type:
Small organic molecule
Emp. Form.:
C37H35N3O3
Mol. Mass.:
569.71
SMILES:
CNc1ccc2cc(ccc2c1)C(=O)N(Cc1ccc(cc1)-c1ccc(cc1)N(C)C)c1cccc(\C=C\C(=O)OC)c1
Structure:
Search PDB for entries with ligand similarity: