Reaction Details Report a problem with these data
Target
Cholecystokinin receptor type A
Ligand
BDBM50013192
Substrate
n/a
Meas. Tech.
ChEBML_50034
IC50
28000±n/a nM
Citation
 Bock, MG; DiPardo, RM; Evans, BE; Rittle, KE; Whitter, WL; Veber, DF; Freidinger, RM; Chang, RS; Chen, TB; Lotti, VJ Cholecystokinin-A receptor ligands based on the kappa-opioid agonist tifluadom. J Med Chem 33:450-5 (1990) [PubMed]  Article 
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCKAR_RAT | Cckar | Cholecystokinin peripheral | Cholecystokinin receptor | Cholecystokinin receptor type A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49676.37
Organism:
RAT
Description:
Cholecystokinin central 0 RAT::P30551
Residue:
444
Sequence:
MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP
  
Inhibitor
Name:
BDBM50013192
Synonyms:
CHEMBL140495 | [5-(2-Fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C24H22FN3O2
Mol. Mass.:
403.4488
SMILES:
Fc1ccccc1C1=NC(CNC(=O)OCc2ccccc2)CNc2ccccc12 |t:8|
Structure:
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