Reaction Details Report a problem with these data
Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50013195
Substrate
n/a
Meas. Tech.
ChEBML_47836
IC50
>100000±n/a nM
Citation
 Bock, MG; DiPardo, RM; Evans, BE; Rittle, KE; Whitter, WL; Veber, DF; Freidinger, RM; Chang, RS; Chen, TB; Lotti, VJ Cholecystokinin-A receptor ligands based on the kappa-opioid agonist tifluadom. J Med Chem 33:450-5 (1990) [PubMed]  Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48445.79
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-2 receptors in HEK 293 cells.
Residue:
447
Sequence:
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50013195
Synonyms:
CHEMBL140749 | Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-1-methyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-ylmethyl]-amide
Type:
Small organic molecule
Emp. Form.:
C22H22FN3OS
Mol. Mass.:
395.493
SMILES:
CN1C(CNC(=O)c2ccsc2)CNC(c2ccccc2F)c2ccccc12
Structure:
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