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Target
Beta-1 adrenergic receptor
Ligand
BDBM50272482
Substrate
n/a
Meas. Tech.
ChEMBL_1712282 (CHEMBL4122331)
IC50
426±n/a nM
Citation
 Kubacka, M; Szkaradek, N; Mogilski, S; Pańczyk, K; Siwek, A; Gryboś, A; Filipek, B; Żmudzki, P; Marona, H; Waszkielewicz, AM Design, synthesis and cardiovascular evaluation of some aminoisopropanoloxy derivatives of xanthone. Bioorg Med Chem 26:3773-3784 (2018) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1R, B1AR | Adrenergic receptor beta | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 | adrenergic Beta1,2 | ADRB1_RAT | Adrb1 | Adrb1r
Type:
Protein
Mol. Mass.:
50486.84
Organism:
Rat
Description:
P18090
Residue:
466
Sequence:
MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSESKV
  
Inhibitor
Name:
BDBM50272482
Synonyms:
CHEMBL4130151
Type:
Small organic molecule
Emp. Form.:
C25H26ClNO5
Mol. Mass.:
455.94
SMILES:
COc1ccccc1CCNCC(O)COc1cccc2c1oc1ccccc1c2=O
Structure:
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