Reaction Details Report a problem with these data
Target
Fatty-acid amide hydrolase 1 [30-579]
Ligand
BDBM50097346
Substrate
n/a
Meas. Tech.
ChEMBL_1724482 (CHEMBL4139760)
IC50
32000±n/a nM
Citation
 Deplano, A; Morgillo, CM; Demurtas, M; Björklund, E; Cipriano, M; Svensson, M; Hashemian, S; Smaldone, G; Pedone, E; Luque, FJ; Cabiddu, MG; Novellino, E; Fowler, CJ; Catalanotti, B; Onnis, V Novel propanamides as fatty acid amide hydrolase inhibitors. Eur J Med Chem 136:523-542 (2017) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1 [30-579]
Synonyms:
Anandamide amidohydrolase 1 | FAAH1_RAT | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty Acid Amide Hydrolic, FAAH | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Fatty-acid amide hydrolase 1 (FAAH) | Fatty-acid amide hydrolase 1 (aa 30-579) | Oleamide hydrolase 1
Type:
Single-pass membrane protein; homodimer
Mol. Mass.:
60474.00
Organism:
Rattus norvegicus (rat)
Description:
P97612 (aa 30-579)
Residue:
550
Sequence:
RWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQPS
  
Inhibitor
Name:
BDBM50097346
Synonyms:
(+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid | 2-(6-Chloro-9H-carbazol-2-yl)-propionic acid | 2-(6-Chloro-9H-carbazol-2-yl)-propionic acid(carprofen) | 2-(6-chloro-9H-carbazol-2-yl)propanoic acid | CARPROFEN | CHEMBL1316 | Rimadyl | Ro-20-5720/000
Type:
Small organic molecule
Emp. Form.:
C15H12ClNO2
Mol. Mass.:
273.714
SMILES:
CC(C(O)=O)c1ccc2c(c1)[nH]c1ccc(Cl)cc21
Structure:
Search PDB for entries with ligand similarity: