Reaction Details Report a problem with these data
Target
Lysophosphatidic acid receptor 1
Ligand
BDBM50285779
Substrate
n/a
Meas. Tech.
ChEMBL_1728748 (CHEMBL4144026)
Kd
23±n/a nM
Citation
 Terakado, M; Suzuki, H; Hashimura, K; Tanaka, M; Ueda, H; Hirai, K; Asada, M; Ikura, M; Matsunaga, N; Saga, H; Shinozaki, K; Karakawa, N; Takada, Y; Minami, M; Egashira, H; Sugiura, Y; Yamada, M; Nakade, S; Takaoka, Y Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia. ACS Med Chem Lett 8:1281-1286 (2017) [PubMed]  Article 
Target
Name:
Lysophosphatidic acid receptor 1
Synonyms:
LPA-1 | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2 | LPA receptor 1 | LPAR1_HUMAN | LPAR1 | EDG2 | LPA1
Type:
Enzyme
Mol. Mass.:
41120.55
Organism:
Human
Description:
Q92633
Residue:
364
Sequence:
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
  
Inhibitor
Name:
BDBM50285779
Synonyms:
CHEMBL4165205
Type:
Small organic molecule
Emp. Form.:
C29H35NO5
Mol. Mass.:
477.6
SMILES:
COc1cc(cc(OC)c1C)[C@@H](O)[C@@H](CC1Cc2ccccc2C1)Cn1ccc(CCC(O)=O)c1 |r|
Structure:
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