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Target
Bcl-2-like protein 1
Ligand
BDBM50315690
Substrate
n/a
Meas. Tech.
ChEMBL_1733218 (CHEMBL4148754)
Ki
2440±n/a nM
Citation
 Abou Samra, A; Robert, A; Gov, C; Favre, L; Eloy, L; Jacquet, E; Bignon, J; Wiels, J; Desrat, S; Roussi, F Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A. Eur J Med Chem 148:26-38 (2018) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50315690
Synonyms:
CHEMBL4177447
Type:
Small organic molecule
Emp. Form.:
C31H30ClN3O4
Mol. Mass.:
544.041
SMILES:
[H][C@]12C[C@H](CCn3cc(nn3)-c3ccccc3)C=C[C@]1([C@H](\C=C(/Cl)c1ccc(cc1)C(O)=O)C=C(C)C2)C(O)=O |r,c:19,t:37|
Structure:
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