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Target
Prolyl hydroxylase EGLN3
Ligand
BDBM50317547
Substrate
n/a
Meas. Tech.
ChEMBL_1733855 (CHEMBL4149391)
IC50
5.5±n/a nM
Citation
 Joharapurkar, AA; Pandya, VB; Patel, VJ; Desai, RC; Jain, MR Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases. J Med Chem 61:6964-6982 (2018) [PubMed]  Article 
Target
Name:
Prolyl hydroxylase EGLN3
Synonyms:
EGLN3 | EGLN3_HUMAN | Egl nine homolog 3 (EGLIN3) | Egl nine homolog 3 (EGLN3)
Type:
Protein
Mol. Mass.:
27265.54
Organism:
Homo sapiens (Human)
Description:
Q9H6Z9
Residue:
239
Sequence:
MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQLAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED
  
Inhibitor
Name:
BDBM50317547
Synonyms:
CHEMBL4163812
Type:
Small organic molecule
Emp. Form.:
C19H27N3O6
Mol. Mass.:
393.4342
SMILES:
OC(=O)CNC(=O)c1c(O)n(C2CCCCC2)c(=O)n(C2CCCCC2)c1=O
Structure:
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