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Target
Thiosulfate sulfurtransferase
Ligand
BDBM50450012
Substrate
n/a
Meas. Tech.
ChEMBL_1741629 (CHEMBL4157379)
IC50
53000±n/a nM
Citation
 Abdeen, S; Kunkle, T; Salim, N; Ray, AM; Mammadova, N; Summers, C; Stevens, M; Ambrose, AJ; Park, Y; Schultz, PG; Horwich, AL; Hoang, QQ; Chapman, E; Johnson, SM Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA). J Med Chem 61:7345-7357 (2018) [PubMed]  Article 
Target
Name:
Thiosulfate sulfurtransferase
Synonyms:
2.8.1.1 | Rhodanese | THTR_HUMAN | TST | Thiosulfate sulfurtransferase
Type:
PROTEIN
Mol. Mass.:
33432.06
Organism:
Homo sapiens
Description:
ChEMBL_118080
Residue:
297
Sequence:
MVHQVLYRALVSTKWLAESIRTGKLGPGLRVLDASWYSPGTREARKEYLERHVPGASFFDIEECRDTASPYEMMLPSEAGFAEYVGRLGISNHTHVVVYDGEHLGSFYAPRVWWMFRVFGHRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLDRSLLKTYEQVLENLESKRFQLVDSRSQGRFLGTEPEPDAVGLDSGHIRGAVNMPFMDFLTEDGFEKGPEELRALFQTKKVDLSQPLIATCRKGVTACHVALAAYLCGKPDVAVYDGSWSEWFRRAPPESRVSQGKSEKA
  
Inhibitor
Name:
BDBM50450012
Synonyms:
CHEMBL4167333
Type:
Small organic molecule
Emp. Form.:
C23H14Cl2N4O7S3
Mol. Mass.:
625.481
SMILES:
[O-][N+](=O)c1cc(ccc1Cl)S(=O)(=O)Nc1ccc(cc1)-c1nc2cc(NS(=O)(=O)c3ccc(Cl)s3)ccc2o1
Structure:
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