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Target
Prostaglandin E synthase
Ligand
BDBM50227631
Substrate
n/a
Meas. Tech.
ChEMBL_1746784 (CHEMBL4181294)
IC50
1360±n/a nM
Citation
 Muthukaman, N; Tambe, M; Deshmukh, S; Pisal, D; Tondlekar, S; Shaikh, M; Sarode, N; Kattige, VG; Pisat, M; Sawant, P; Honnegowda, S; Karande, V; Kulkarni, A; Behera, D; Jadhav, SB; Sangana, RR; Gudi, GS; Khairatkar-Joshi, N; Gharat, LA Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1. Bioorg Med Chem Lett 27:5131-5138 (2017) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
Prostaglandin E2 synthase-1 ( mPGES-1) | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | PTGES_HUMAN | PTGES | MGST1L1 | MPGES1 | PGES | PIG12 | Prostaglandin E synthase/G/H synthase 2
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Human
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM50227631
Synonyms:
2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile | CHEMBL412099
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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