Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50452446
Substrate
n/a
Meas. Tech.
ChEMBL_1747515 (CHEMBL4182025)
EC50
317±n/a nM
Citation
 Flohr, AHutter, RMueller, BBohnert, CPellisson, MSchaffhauser, H Discovery of the first low-shift positive allosteric modulators for the muscarinic M1 receptor. Bioorg Med Chem Lett 27:5415-5419 (2017) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50452446
Synonyms:
CHEMBL4209299
Type:
Small organic molecule
Emp. Form.:
C16H11ClFNS
Mol. Mass.:
303.782
SMILES:
Fc1ccccc1C1=CCC(=S)Nc2ccc(Cl)cc12 |t:8|
Structure:
Search PDB for entries with ligand similarity: