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Target
Virulence sensor histidine kinase PhoQ
Ligand
BDBM227589
Substrate
n/a
Meas. Tech.
ChEMBL_1751446 (CHEMBL4186206)
Kd
715000±n/a nM
Citation
 Vo, CD; Shebert, HL; Zikovich, S; Dryer, RA; Huang, TP; Moran, LJ; Cho, J; Wassarman, DR; Falahee, BE; Young, PD; Gu, GH; Heinl, JF; Hammond, JW; Jackvony, TN; Frederick, TE; Blair, JA Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. Bioorg Med Chem Lett 27:5235-5244 (2017) [PubMed]  Article 
Target
Name:
Virulence sensor histidine kinase PhoQ
Synonyms:
2.7.13.3 | 3.1.3.- | PHOQ_SALTY | Sensor histidine protein kinase/phosphatase PhoQ | Virulence sensor histidine kinase PhoQ | phoQ | phoZ | phoZ
Type:
PROTEIN
Mol. Mass.:
55464.52
Organism:
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Description:
ChEMBL_102404
Residue:
487
Sequence:
MNKFARHFLPLSLRVRFLLATAGVVLVLSLAYGIVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNKISVELPENLDMQSPTMTLIYDETGKLLWTQRNIPWLIKSIQPEWLKTNGFHEIETNVDATSTLLSEDHSAQEKLKEVREDDDDAEMTHSVAVNIYPATARMPQLTIVVVDTIPIELKRSYMVWSWFVYVLAANLLLVIPLLWIAAWWSLRPIEALAREVRELEDHHREMLNPETTRELTSLVRNLNQLLKSERERYNKYRTTLTDLTHSLKTPLAVLQSTLRSLRNEKMSVSKAEPVMLEQISRISQQIGYYLHRASMRGSGVLLSRELHPVAPLLDNLISALNKVYQRKGVNISMDISPEISFVGEQNDFVEVMGNVLDNACKYCLEFVEISARQTDDHLHIFVEDDGPGIPHSKRSLVFDRGQRADTLRPGQGVGLAVAREITEQYAGQIIASDSLLGGARMEVVFGRQHPTQKEE
  
Inhibitor
Name:
BDBM227589
Synonyms:
Radicicol
Type:
Small organic molecule
Emp. Form.:
C18H17ClO6
Mol. Mass.:
364.777
SMILES:
C[C@@H]1C[C@H]2O[C@@H]2\C=C/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1 |r,c:7,t:9|
Structure:
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