Reaction Details
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Report a problem with these dataTarget
Signal transducer and activator of transcription 3
Ligand
BDBM50456768
Substrate
n/a
Meas. Tech.
ChEMBL_1758066 (CHEMBL4193074)
IC50
25740±n/a nM
Citation
Del Prete, D; Taglialatela-Scafati, O; Minassi, A; Sirignano, C; Cruz, C; Bellido, ML; Muñoz, E; Appendino, G Electrophilic Triterpenoid Enones: A Comparative Thiol-Trapping and Bioactivity Study. J Nat Prod 80:2276-2283 (2017) [PubMed] Article More Info.:
Target
Name:
Signal transducer and activator of transcription 3
Synonyms:
Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3) | STAT3_HUMAN | STAT3 | APRF
Type:
Protein
Mol. Mass.:
88064.31
Organism:
Human
Description:
P40763
Residue:
770
Sequence:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
Inhibitor
Name:
BDBM50456768
Synonyms:
CHEMBL4211885
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
