Target
Mitogen-activated protein kinase 14
Ligand
BDBM14831
Substrate
n/a
Meas. Tech.
ChEMBL_1759775 (CHEMBL4194783)
IC50
794±n/a nM
Citation
 Young, RJLeeson, PD Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations. J Med Chem 61:6421-6467 (2018) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM14831
Synonyms:
3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-(4-chlorophenyl)urea | 3-(4-chlorophenyl)-1-(2-methyl-5-tert-butyl-pyrazol-3-yl)urea | CHEMBL87277 | Dopamine D2 receptor and serotonin 2a receptor | diaryl urea compound 2 | diaryl urea inhibitor 1
Type:
Small organic molecule
Emp. Form.:
C15H19ClN4O
Mol. Mass.:
306.791
SMILES:
Cn1nc(cc1NC(=O)Nc1ccc(Cl)cc1)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity: