Reaction Details Report a problem with these data
Target
Retinoic acid receptor gamma
Ligand
BDBM31888
Substrate
n/a
Meas. Tech.
ChEMBL_1760055 (CHEMBL4195063)
EC50
46±n/a nM
Citation
Thoreau, E; Arlabosse, JM; Bouix-Peter, C; Chambon, S; Chantalat, L; Daver, S; Dumais, L; Duvert, G; Feret, A; Ouvry, G; Pascau, J; Raffin, C; Rodeville, N; Soulet, C; Tabet, S; Talano, S; Portal, T Structure-based design of Trifarotene (CD5789), a potent and selective RAR? agonist for the treatment of acne. Bioorg Med Chem Lett 28:1736-1741 (2018) [PubMed] Article
More Info.:
Target
Name:
Retinoic acid receptor gamma
Synonyms:
NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoic acid receptor gamma | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50345.43
Organism:
Human
Description:
ChEMBL_1458016
Residue:
454
Sequence:
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA