Reaction Details Report a problem with these data
Target
4-aminobutyrate aminotransferase, mitochondrial
Ligand
BDBM50021645
Substrate
n/a
Meas. Tech.
ChEBML_68398
Ki
91000±n/a nM
Citation
 Wermuth, CG; Bourguignon, JJ; Schlewer, G; Gies, JP; Schoenfelder, A; Melikian, A; Bouchet, MJ; Chantreux, D; Molimard, JC; Heaulme, M Synthesis and structure-activity relationships of a series of aminopyridazine derivatives of gamma-aminobutyric acid acting as selective GABA-A antagonists. J Med Chem 30:239-49 (1987) [PubMed]  Article 
Target
Name:
4-aminobutyrate aminotransferase, mitochondrial
Synonyms:
(S)-3-amino-2-methylpropionate transaminase | 4-aminobutyrate aminotransferase, mitochondrial | ABAT | GABA aminotransferase | GABA transaminase | GABA-AT | GABA-T | GABAT | GABT_HUMAN | Gamma-amino-N-butyrate transaminase | L-AIBAT
Type:
PROTEIN
Mol. Mass.:
56449.39
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459248
Residue:
500
Sequence:
MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQNASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYRSKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLLDLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK
  
Inhibitor
Name:
BDBM50021645
Synonyms:
(3-Phenyl-thioureido)-acetic acid | CHEMBL311337 | N-Phenylthiohydantoic acid
Type:
Small organic molecule
Emp. Form.:
C9H10N2O2S
Mol. Mass.:
210.253
SMILES:
OC(=O)CNC(=S)Nc1ccccc1
Structure:
Search PDB for entries with ligand similarity: