Target
Transthyretin
Ligand
BDBM50240510
Substrate
n/a
Meas. Tech.
ChEMBL_1765443 (CHEMBL4200690)
Kd
407±n/a nM
Citation
 Miller, MPal, AAlbusairi, WJoo, HPappas, BHaque Tuhin, MTLiang, DJampala, RLiu, FKhan, JFaaij, MPark, MChan, WGraef, IZamboni, RKumar, NFox, JSinha, UAlhamadsheh, M Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. J Med Chem 61:7862-7876 (2018) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Human
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50240510
Synonyms:
CHEMBL898 | DIFLUNISAL
Type:
Small organic molecule
Emp. Form.:
C13H8F2O3
Mol. Mass.:
250.1976
SMILES:
OC(=O)c1cc(ccc1O)-c1ccc(F)cc1F
Structure:
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