Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM50459083
Substrate
n/a
Meas. Tech.
ChEMBL_1765443 (CHEMBL4200690)
Kd
251±n/a nM
Citation
 Miller, M; Pal, A; Albusairi, W; Joo, H; Pappas, B; Haque Tuhin, MT; Liang, D; Jampala, R; Liu, F; Khan, J; Faaij, M; Park, M; Chan, W; Graef, I; Zamboni, R; Kumar, N; Fox, J; Sinha, U; Alhamadsheh, M Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. J Med Chem 61:7862-7876 (2018) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Human
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50459083
Synonyms:
CHEMBL4210824
Type:
Small organic molecule
Emp. Form.:
C16H19FN2O3
Mol. Mass.:
306.3321
SMILES:
Cc1nn(C)c(C)c1CCCOc1cc(ccc1F)C(O)=O
Structure:
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