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Target
Alpha-crystallin B chain
Ligand
BDBM20182
Substrate
n/a
Meas. Tech.
ChEMBL_1765923 (CHEMBL4201170)
EC50
320±n/a nM
Citation
 Yang, X; Chen, XJ; Yang, Z; Xi, YB; Wang, L; Wu, Y; Yan, YB; Rao, Y Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation. J Med Chem 61:8693-8706 (2018) [PubMed]  Article 
Target
Name:
Alpha-crystallin B chain
Synonyms:
Alpha(B)-crystallin | Alpha-crystallin B chain | Heat shock protein beta-5 | Renal carcinoma antigen NY-REN-27 | Rosenthal fiber component | CRYAB_HUMAN | CRYAB | CRYA2 | HSPB5
Type:
PROTEIN
Mol. Mass.:
20162.17
Organism:
Human
Description:
ChEMBL_109886
Residue:
175
Sequence:
MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSWFDTGLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK
  
Inhibitor
Name:
BDBM20182
Synonyms:
(1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol | 25-hydroxycholesterol | 25-Hydroxycholesterol (25OH)
Type:
Small organic molecule
Emp. Form.:
C27H46O2
Mol. Mass.:
402.35
SMILES:
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C |t:15|
Structure:
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