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Target
Polyunsaturated fatty acid 5-lipoxygenase
Ligand
BDBM50023166
Substrate
n/a
Meas. Tech.
ChEBML_3924
IC50
420±n/a nM
Citation
 Summers, JB; Gunn, BP; Martin, JG; Mazdiyasni, H; Stewart, AO; Young, PR; Goetze, AM; Bouska, JB; Dyer, RD; Brooks, DW Orally active hydroxamic acid inhibitors of leukotriene biosynthesis. J Med Chem 31:3-5 (1988) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid 5-lipoxygenase
Synonyms:
LOX5_RAT | Alox5 | Arachidonate 5-lipoxygenase
Type:
PROTEIN
Mol. Mass.:
78082.31
Organism:
Rat
Description:
ChEMBL_1432947
Residue:
673
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDEELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGCNPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPCTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFHIHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGLFDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEAIQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYYYLSPDRIPNSVAI
  
Inhibitor
Name:
BDBM50023166
Synonyms:
N-Hydroxy-N-[1-(4-isobutyl-phenyl)-ethyl]-acetamide | CHEMBL444271
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(C)Cc1ccc(cc1)C(C)N(O)C(C)=O
Structure:
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