Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3
Ligand
BDBM50462013
Substrate
n/a
Meas. Tech.
ChEMBL_1772378 (CHEMBL4224490)
IC50
7000±n/a nM
Citation
 Kim, YH; Yoon, YJ; Lee, YJ; Kim, CH; Lee, S; Choung, DH; Han, DC; Kwon, BM Piperlongumine derivative, CG-06, inhibits STAT3 activity by direct binding to STAT3 and regulating the reactive oxygen species in DU145 prostate carcinoma cells. Bioorg Med Chem Lett 28:2566-2572 (2018) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 3
Synonyms:
Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3) | STAT3_HUMAN | STAT3 | APRF
Type:
Protein
Mol. Mass.:
88064.31
Organism:
Human
Description:
P40763
Residue:
770
Sequence:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
  
Inhibitor
Name:
BDBM50462013
Synonyms:
CHEBI:8241 | Piplartine
Type:
Small organic molecule
Emp. Form.:
C17H19NO5
Mol. Mass.:
317.34
SMILES:
COc1cc(cc(c1OC)OC)/C=C/C(=O)N2CCC=CC2=O
Structure:
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